Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8⁺ T cell responses following COVID-19.

Roukens, Anna H E; Pothast, Cilia R; König, Marion; Huisman, Wesley; Dalebout, Tim; Tak, Tamar; Azimi, Shohreh; Kruize, Yvonne; Hagedoorn, Renate S; Zlei, Mihaela; Staal, Frank J T; de Bie, Fenna J; van Dongen, Jacques J M; Arbous, Sesmu M; Zhang, Jaimie L H; Verheij, Maaike; Prins, Corine; van der Does, Anne M; Hiemstra, Pieter S; de Vries, Jutte J C; Janse, Jacqueline J; Roestenberg, Meta; Myeni, Sebenzile K; Kikkert, Marjolein; Yazdanbakhsh, Maria; Heemskerk, Mirjam H M; Smits, Hermelijn H; Jochems, Simon P.

Nat Immunol ; 23(1): 23-32, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34937933

2.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt, Jorg; Fleskens, Veerle; Tiemessen, Machteld M; Mokry, Michal; van Boxtel, Ruben; Meerding, Jenny; Pals, Cornelieke E G M; Kurek, Dorota; Baert, Miranda R M; Delemarre, Eveline M; Gröne, Andrea; Koerkamp, Marianne J A Groot; Sijts, Alice J A M; Nieuwenhuis, Edward E S; Maurice, Madelon M; van Es, Johan H; Ten Berge, Derk; Holstege, Frank C; Staal, Frank J T; Zaiss, Dietmar M W; Prakken, Berent J; Coffer, Paul J.

Immunity ; 39(2): 298-310, 2013 Aug 22.

Artigo em Inglês | MEDLINE | ID: mdl-23954131

3.

Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning.

Schwarzer, Adrian; Talbot, Steven R; Selich, Anton; Morgan, Michael; Schott, Juliane W; Dittrich-Breiholz, Oliver; Bastone, Antonella L; Weigel, Bettina; Ha, Teng Cheong; Dziadek, Violetta; Gijsbers, Rik; Thrasher, Adrian J; Staal, Frank J T; Gaspar, Hubert B; Modlich, Ute; Schambach, Axel; Rothe, Michael.

Mol Ther ; 29(12): 3383-3397, 2021 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-34174440

4.

IL3 Has a Detrimental Effect on Hematopoietic Stem Cell Self-Renewal in Transplantation Settings.

Tajer, Parisa; Canté-Barrett, Kirsten; Naber, Brigitta A E; Vloemans, Sandra A; van Eggermond, Marja C J A; van der Hoorn, Marie-Louise; Pike-Overzet, Karin; Staal, Frank J T.

Int J Mol Sci ; 23(21)2022 Oct 22.

Artigo em Inglês | MEDLINE | ID: mdl-36361533

5.

Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.

Staal, Frank J T; Clevers, Hans.

Immunity ; 37(5): 761-3, 2012 Nov 16.

Artigo em Inglês | MEDLINE | ID: mdl-23159221

6.

ImSpectR - R package to quantify immune repertoire diversity in spectratype and repertoire sequencing data.

Cordes, Martijn; Pike-Overzet, Karin; van Eggermond, Marja; Vloemans, Sandra; Baert, Miranda R; Garcia-Perez, Laura; Staal, Frank J T; Reinders, Marcel J T; van den Akker, Erik.

Bioinformatics ; 2019 Oct 30.

Artigo em Inglês | MEDLINE | ID: mdl-31665245

7.

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

Rahman, Sunniyat; Magnussen, Michael; León, Theresa E; Farah, Nadine; Li, Zhaodong; Abraham, Brian J; Alapi, Krisztina Z; Mitchell, Rachel J; Naughton, Tom; Fielding, Adele K; Pizzey, Arnold; Bustraan, Sophia; Allen, Christopher; Popa, Teodora; Pike-Overzet, Karin; Garcia-Perez, Laura; Gale, Rosemary E; Linch, David C; Staal, Frank J T; Young, Richard A; Look, A Thomas; Mansour, Marc R.

Blood ; 129(24): 3221-3226, 2017 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-28270453

8.

Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus.

Brugman, Martijn H; Wiekmeijer, Anna-Sophia; van Eggermond, Marja; Wolvers-Tettero, Ingrid; Langerak, Anton W; de Haas, Edwin F E; Bystrykh, Leonid V; van Rood, Jon J; de Haan, Gerald; Fibbe, Willem E; Staal, Frank J T.

Proc Natl Acad Sci U S A ; 112(44): E6020-7, 2015 Nov 03.

Artigo em Inglês | MEDLINE | ID: mdl-26483497

9.

Axin2-mTurquoise2: A novel reporter mouse model for the detection of canonical Wnt signalling.

de Roo, Jolanda J D; Breukel, Cor; Chhatta, Amiet R; Linssen, Margot M; Vloemans, Sandra A; Salvatori, Daniela; Mikkers, Harald M M; Verbeek, Sjef J; Staal, Frank J T.

Genesis ; 55(10)2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28875532

10.

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.

Holstege, Henne; Pfeiffer, Wayne; Sie, Daoud; Hulsman, Marc; Nicholas, Thomas J; Lee, Clarence C; Ross, Tristen; Lin, Jue; Miller, Mark A; Ylstra, Bauke; Meijers-Heijboer, Hanne; Brugman, Martijn H; Staal, Frank J T; Holstege, Gert; Reinders, Marcel J T; Harkins, Timothy T; Levy, Samuel; Sistermans, Erik A.

Genome Res ; 24(5): 733-42, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-24760347

11.

BETting on stem cell expansion.

Staal, Frank J T; Fibbe, Willem E.

Blood ; 136(21): 2364-2365, 2020 11 19.

Artigo em Inglês | MEDLINE | ID: mdl-33211833

12.

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells.

Redeker, Anke; Welten, Suzanne P M; Baert, Miranda R M; Vloemans, Sandra A; Tiemessen, Machteld M; Staal, Frank J T; Arens, Ramon.

J Immunol ; 195(10): 4792-801, 2015 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-26453748

13.

Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.

Wiekmeijer, Anna-Sophia; Pike-Overzet, Karin; IJspeert, Hanna; Brugman, Martijn H; Wolvers-Tettero, Ingrid L M; Lankester, Arjan C; Bredius, Robbert G M; van Dongen, Jacques J M; Fibbe, Willem E; Langerak, Anton W; van der Burg, Mirjam; Staal, Frank J T.

J Allergy Clin Immunol ; 137(2): 517-526.e3, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26441229

14.

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice.

Hoeke, Geerte; Khedoe, P Padmini S J; van Diepen, Janna A; Pike-Overzet, Karin; van de Ven, Britt; Vazirpanah, Nadia; Mol, Isabel; Hiemstra, Pieter S; Staal, Frank J T; Stienstra, Rinke; Netea, Mihai G; Dinarello, Charles A; Rensen, Patrick C N; Berbée, Jimmy F P.

Int J Mol Sci ; 18(8)2017 Aug 09.

Artigo em Inglês | MEDLINE | ID: mdl-28792474

15.

T Cell factor 1 represses CD8+ effector T cell formation and function.

Tiemessen, Machteld M; Baert, Miranda R M; Kok, Lianne; van Eggermond, Marja C J A; van den Elsen, Peter J; Arens, Ramon; Staal, Frank J T.

J Immunol ; 193(11): 5480-7, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25355919

16.

WNT signalling and haematopoiesis: a WNT-WNT situation.

Staal, Frank J T; Clevers, Hans C.

Nat Rev Immunol ; 5(1): 21-30, 2005 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-15630426

17.

An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in acute myeloid leukemia.

Taskesen, Erdogan; Staal, Frank J T; Reinders, Marcel J T.

BMC Bioinformatics ; 16 Suppl 4: S4, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25734857

18.

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

Tiemessen, Machteld M; Baert, Miranda R M; Schonewille, Tom; Brugman, Martijn H; Famili, Farbod; Salvatori, Daniela C F; Meijerink, Jules P P; Ozbek, Ugur; Clevers, Hans; van Dongen, Jacques J M; Staal, Frank J T.

PLoS Biol ; 10(11): e1001430, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23185135

19.

Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.

Bijkerk, Roel; van Solingen, Coen; de Boer, Hetty C; van der Pol, Pieter; Khairoun, Meriem; de Bruin, Ruben G; van Oeveren-Rietdijk, Annemarie M; Lievers, Ellen; Schlagwein, Nicole; van Gijlswijk, Danielle J; Roeten, Marko K; Neshati, Zeinab; de Vries, Antoine A F; Rodijk, Mark; Pike-Overzet, Karin; van den Berg, Yascha W; van der Veer, Eric P; Versteeg, Henri H; Reinders, Marlies E J; Staal, Frank J T; van Kooten, Cees; Rabelink, Ton J; van Zonneveld, Anton Jan.

J Am Soc Nephrol ; 25(8): 1710-22, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24610930

20.

De novo generation of a functional human thymus from induced pluripotent stem cells.

Chhatta, Amiet R; Cordes, Martijn; Hanegraaf, Maaike A J; Vloemans, Sandra; Cupedo, Tom; Cornelissen, Jan J; Carlotti, Francoise; Salvatori, Daniela; Pike-Overzet, Karin; Fibbe, Willem E; Hoeben, Rob C; Mikkers, Harald M M; Staal, Frank J T.

J Allergy Clin Immunol ; 144(5): 1416-1419.e7, 2019 11.

Artigo em Inglês | MEDLINE | ID: mdl-31323248

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